Work

Moderate forced running exercise induces cartilage adaptation but exacerbates the molecular cartilage phenotype of type IX collagen knockout mice

Year: 2026

Type: article

Abstract: Moderate forced running exercise only slightly enhances the cartilage phenotype in aging female type IX collagen knockout mice and induces local, nondegenerative, structural and molecular adaptations in the articular cartilage ECM. Alterations in the cartilage phenotype do not depend on the age of the mice.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00959.2025

Authors: Miriam Weyers, Thomas Li, Maren Dreiner, Daniela Mählich, Charlotte Lorenz, Luisa de Roy, Paola Zigrino, Lin Han, Bent Brachvogel, Frank Zaucke, Anja Niehoff

Institutions: German Sport University Cologne, Drexel University, Universität Ulm, University of Cologne, University Hospital Cologne, Goethe University Frankfurt, University Hospital Frankfurt

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Deutsche Forschungsgemeinschaft

Awards: G1135006492, FOR 2722: Neue molekulare Determinanten der Homöostase der muskuloskelettalen extrazellulären Matrix ein systemischer Ansatz, Aufklärung neuer Pathomechanismen von Plastin 3 assoziierten Knochen und Knorpelerkrankungen

OpenAlex ID: W7161744447

FWCI: 4.679

Cites: 86

Cited by: 1

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