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Pathomorphological and Immunohistochemical Features of Chronic Placental Insufficiency in Congenital Infections Under the Conditions of Karakalpakstan

Year: 2026

Type: article

Abstract: Chronic placental insufficiency (CPI) remains a critical obstetric complication, serving as a primary vector for intrauterine growth restriction, preterm birth, and perinatal mortality. In regions experiencing severe ecological degradation, such as the Republic of Karakalpakstan in the Aral Sea disaster zone, the etiology of CPI is profoundly compounded by environmental toxicity, high regional rates of maternal anemia, and the prevalent transmission of congenital (TORCH) infections. This comprehensive report investigates the synergistic impact of environmental factors and infectious agents on the pathomorphological and immunohistochemical (IHC) architecture of the human placenta. Utilizing advanced digital histomorphometry and computational image analysis, the study quantifies key biomarkers associated with angiogenesis (VEGF), cellular proliferation (Ki-67), apoptosis (Caspase-3), and localized inflammatory responses (CD68).

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20289692

Authors: Mamutov, Sharap Iskanderovich, Atazhanov, Azizbek Amangalievich, Alauatdinova, Ziyuar Khojabay qizi

Institution: Tashkent Medical Academy

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7161748623

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