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1,4-Dihydroxy-1,8-napthyridinone (DHN) analogs as HIV-1 reverse transcriptase-associated RNase H inhibitors

Year: 2026

Type: article

Source: Bioorganic Chemistry

DOI: 10.1016/j.bioorg.2026.110119

Authors: Muhammad Syafiq Bin Shahari, Samuel Offei, Huanchun Zhang, Janani Prahlad, Jacob P. Mahoney, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang

Institutions: University of Minnesota, Emory University, Children's Healthcare of Atlanta

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Foundation for the National Institutes of Health, University of Minnesota, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Award: Novel antivirals targeting the RNase H activity of HIV reverse transcriptase

OpenAlex ID: W7165002900

FWCI:

Cites: 33

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Related to: 10