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The Role of Immuno-biochemical Markers in the Active Stage of Chronic Rheumatic Heart Disease in Children

Year: 2026

Type: article

Abstract: Chronic rheumatic heart disease (CRHD) remains one of the most important acquired cardiovascular diseases in children and adolescents. The disease develops due to autoimmune inflammatory reactions after group A beta-hemolytic streptococcal infection and is characterized by progressive valvular damage, myocardial inflammation, and chronic cardiac insufficiency. The present study investigated serum levels of interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and procalcitonin (PCT) in children with CRHD. Elevated TNF-α, CRP, and PCT together with reduced IL-10 were observed during active inflammatory stages. These biomarkers demonstrated high diagnostic and prognostic significance.

Source: Journal of Multidisciplinary Sciences and Innovations

DOI: 10.5281/zenodo.20328941

Author: Bobojonov, Khurshid Jumaniyozovich

Institution: Asia International University

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7161964009

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