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Novel Compounds as TREM2 Modulators for Treating Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, and Nasu-Hakola Disease

Year: 2026

Type: editorial

Abstract: Provided herein are novel compounds as TREM2 modulators, pharmaceutical compositions, use of such compounds in treating Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and Nasu-Hakola disease, and processes for preparing such compounds.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00249

Authors: Ram W. Sabnis, Anika R. Sabnis

Institution: Mayo Clinic

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7161977834

Cites: 6

Cited by: 1

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