Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder
Year: 2026
Type: article
Study design: Observational Study
Abstract: Isolated/idiopathic rapid-eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early form of α -synuclein-related neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies. Clinical reports suggest that iRBD is more common in individuals with Post-Traumatic Stress Disorder (PTSD) compared to those without PTSD. We conducted polygenic risk score (PRS), genetic correlation, and Mendelian randomization analyses to explore potential genetic and/or causal associations between PTSD and iRBD. Dopamine transporter imaging binding status was also examined in iRBD patients with (N = 6) and without PTSD (N = 32). While not supporting a causal relationship, genetic analyses revealed a significant association between PTSD and iRBD, consistent with the exploratory imaging substudy. These findings suggest that individuals genetically at risk for PTSD may also be at higher risk for iRBD. Further investigation of iRBD in individuals with PTSD may help inform potential neurodegenerative risk.
Source: npj Parkinson s Disease
Authors: Morvarid Ghamgosar Shahkhali, Lang Liu, Mohammad H. Ghamgosar Shahkhali, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Isabelle Arnulf, Pauline Dodet, Yo-El Ju, Michele T. M. Hu, Jacques Y. Montplaisir, Jean-François Gagnon, Alex Desautels, Abubaker Ibrahim, Ambra Stefani, Birgit Högl, Merve Aktan-Süzgün, Alex Iranzo, Mónica Serradell, Angelica Montini, Gerard Maya, Carles Gaig, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Yves Dauvilliers, Karel Sonka, David Kemlink, Petr Dusek, Michael Sommerauer, Gültekin Tamgüney, Michela Figorilli, Monica Puligheddu, Valerie Cochen De Cock, Wolfgang Oertel, Annette Janzen, Elena Antelmi, Brit Mollenhauer, Friederike Sixel-Doring, Michele Terzaghi, Giuseppe Fiamingo, Matej Skorvanek, Kristina Kulcsarova, Beatriz Abril, Luigi Ferini-Strambi, Jitka Bušková, Beatrice Orso, Pietro Mattioli, Dario Arnaldi, Femke Dijkstra, Mineke Viaene, Bradley F. Boeve, Owen A. Ross, Guy A. Rouleau, Lee E. Neilson, Jonathan E. Elliott, Miranda M. Lim, Ronald B. Postuma, Ziv Gan-Or
Institutions: Montreal Neurological Institute and Hospital, McGill University, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut du Cerveau, Washington University in St. Louis, University of Oxford, Hôpital du Sacré-Cœur de Montréal, Canadian Sleep & Circadian Network, Université de Montréal, Université du Québec à Montréal, Innsbruck Medical University, Universität Innsbruck, Biomedical Research Networking Center on Neurodegenerative Diseases, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of Udine, Inserm, Centre Hospitalier Universitaire de Montpellier, Institute for Neurosciences of Montpellier, Charles University, General University Hospital in Prague, University of Bonn, Forschungszentrum Jülich, University of Cologne, University Hospital Bonn, University Hospital Cologne, Heinrich Heine University Düsseldorf, University of Cagliari, IMT Mines Alès, EuroMov Digital Health in Motion, Philipps University of Marburg, University of Verona, Universitätsmedizin Göttingen, Paracelsus Elena Klinik Kassel, University of Göttingen, University of Pavia, University of Pavol Jozef Šafárik, Univerzitná Nemocnica Louisa Pasteura, Centre Hospitalier Universitaire de Nîmes, Vita-Salute San Raffaele University, National Institute of Mental Health, University of Genoa, Ospedale Policlinico San Martino, Antwerp University Hospital, Mayo Clinic, Mayo Clinic in Florida, Oregon Health & Science University, Portland VA Medical Center, VA Northwest Network, VA Portland Health Care System
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
Funders: Galen and Hilary Weston Foundation, Michael J. Fox Foundation for Parkinson's Research, Univerzita Karlova v Praze, McGill University, Université du Québec à Montréal, Università degli Studi di Cagliari, Compute Canada, Consortium canadien en neurodégénérescence associée au vieillissement, University of Oxford, European Commission, Institut National de la Santé et de la Recherche Médicale, Forschungszentrum Jülich, Heinrich-Heine-Universität Düsseldorf, Università degli Studi di Genova, Università degli Studi di Pavia, Université de Montréal, Centre Hospitalier Régional Universitaire de Montpellier, Agentúra na Podporu Výskumu a Vývoja, Universitat de Barcelona, Università degli Studi di Verona, Universität zu Köln, Università degli Studi di Udine, Agentura Pro Zdravotnický Výzkum České Republiky, Medizinische Universität Innsbruck, Canada First Research Excellence Fund, Universität Innsbruck, Universitätsklinikum Köln, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Centre Hospitalier Universitaire de Nîmes, National Institutes of Health, Fonds de Recherche du Québec - Santé, Instituto de Salud Carlos III, National Institute on Aging, National Institute of Mental Health
Awards: G1269895679, Biomarkery prodromálnych a genetických foriem Parkinsonovej choroby, G1309605592, G1940663492, G2486988760, G3036763132, G3120673997, G3173811024, G3858648280, G3939087926, G3949031371, G4065343422, G413369726, G5561241740, G6693067474, G6948331134, G708815790, G8233866395, G8506111834, G882351932, Center for Alzheimer's and Related Dementias: iPSCs to study APOE heterogeneity in Alzheimers disease and Alzheimers disease-related dementias (iDA), Mayo Alzheimer's Disease Research Center
OpenAlex ID: W7161979049
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