Laying the Foundation for Clinically Actionable Genomic Subtyping in Diffuse Large B-cell Lymphoma
Year: 2026
Type: review
Abstract: Diffuse large B-cell lymphoma (DLBCL) is clinically and genetically heterogeneous. The existence of genetically defined subtypes with therapeutic implications is clear. Additional considerations that are yet to be fully resolved include defining boundaries between discrete classes, relevant molecular data types, and handling of unclassifiable/composite cases. In this review, we juxtapose points of view on the topic from experts in the field, outline practical workflow considerations, and distill lessons from clinical trials. These synthesize experimental design and analytic considerations that inform the development and evaluation of clinically relevant DLBCL subtyping approaches. SIGNIFICANCE: The most meaningful way to stratify DLBCL remains unresolved, and this represents a significant barrier to adopting a precision medicine paradigm.
Source: Blood Cancer Discovery
Institutions: Dana-Farber Cancer Institute, National Institutes of Health, National Cancer Institute, Wellcome/MRC Cambridge Stem Cell Institute, University of Cambridge, Shanghai Jiao Tong University, Shanghai Institute of Hematology, Columbia University, Stanford Medicine, Stanford University, Simon Fraser University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7160944822