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Sex differences in the peripheral determinants of oxygen transport and utilization in patients with heart failure with preserved ejection fraction

Year: 2026

Type: article

Abstract: Females with heart failure with preserved ejection fraction have lower muscle oxygen diffusive conductance during peak exercise compared with males. Interventions to improve muscle quality and diffusive capacity are of particular importance for improving peripheral limitations to exercise in females with HFpEF.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00254.2026

Authors: Christopher M. Hearon, Rachel J. Skow, Denis J. Wakeham, Claire Kissell, Tiffany L. Brazile, Michael D. Nelson, Miles F. Bartlett, Jimin Ren, Mitchel Samels, James P. MacNamara, Ziba Taherzadeh, Kevin Lutz, Benjamin D. Levine, Paul J. Fadel, Mark J. Haykowsky, Satyam Sarma

Institutions: The University of Texas Southwestern Medical Center, University of Alberta, The University of Texas at Arlington, San Diego State University, University of Virginia Health System

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Heart, Lung, and Blood Institute

Awards: Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure with Preserved Ejection Fraction, Training in Cardiovascular Research, Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Precision Therapy Based on Patient Specific Pathophysiology

OpenAlex ID: W7161983300

FWCI: 9.473

Cites: 72

Cited by: 1

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