Work

Directed Evolution of Threonine Aldolases for the Photobiocatalytic Synthesis of β-Branched-α-Tetrasubstituted and Other Noncanonical Amino Acids

Year: 2026

Type: article

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.6c03303

Authors: Tian-Ci Wang, Xiangyu Zhang, Zheng Zhang, Guodong Rao, Zhiyu Bo, Pei-Pei Xie, Jiedong Li, Qiang Yang, Xiaoyong Li, R. David Britt, Jiang Wang, Peng Liu, Yang Yang

Institutions: University of California, Santa Barbara, University of Pittsburgh, University of California, Davis, Eli Lilly (United States), Howard Hughes Medical Institute

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: National Science Foundation, David and Lucile Packard Foundation, Howard Hughes Medical Institute, Alfred P. Sloan Foundation, Camille and Henry Dreyfus Foundation, Eli Lilly and Company, National Institutes of Health

Awards: Integrated Computational and Mechanistic Investigation on New Reactivity and Selectivity in Emerging Enzymatic Reactions, G1760923948, G3653883262, Category I. Computing without Boundaries: Cyberinfrastructure for the Long Tail of Science, MRI: Acquisition of Cutting-Edge GPU and MPI Nodes for the Interdisciplinary Pitt Center for Research Computing, G6620902255, Category I: Bridges-2: Scalable Converged Computing, Data, and Analytics for Rapidly Evolving Science and Engineering Research, G9000034938, Pyridoxal Radical Biocatalysis for the Stereoselective Production of Non-Canonical Amino Acids

OpenAlex ID: W7161986118

FWCI: 10.93

Cites: 105

Cited by: 6

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