Kawasaki-like disease associated with COVID-19 (Kawa-COVID-19); an overview of recent evident
Year: 2025
Type: article
Abstract: Kawa-COVID-19 represents a new pediatric inflammatory syndrome associated with SARS-CoV-2 infection that mimics but is distinct from classic Kawasaki disease. Kawasaki-like disease associated with COVID-19 is a serious inflammatory condition that emerged during the COVID-19 pandemic. In Kawa-COVID-19, autoantibodies specifically target endothelial cells by recognizing both constitutive and induced endothelial antigens, often due to molecular mimicry, leading to complement activation, immune-mediated cytotoxicity, and endothelial dysfunction. These processes collectively contribute to vascular inflammation, coagulopathy, and the multisystem manifestations of the disease. This description incorporates the current evidence on how autoantibodies target endothelial cells in Kawa-COVID-19, highlighting key immunopathological mechanisms underlying vascular injury. Additionally, acute kidney injury, in this disease can be prerenal due to hypoperfusion or heart failure or intrinsic renal AKI from tubulointerstitial nephritis, hemolytic uremic syndrome, immune-complex nephropathy, or causes related to Kawasaki disease shock syndrome.
Author: Paniz Pourpashang
Institutions: Bahrami Hospital, Tehran University of Medical Sciences
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7161987803