Metal-Free Induced Tandem Cyclization of 2-Aryl- N -Methacryloyl Indoles via 1,2-Hydrogen Atom Transfer
Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide This article reports a photoredox-catalyzed tandem cyclization of 2-aryl- N -methacryloyl indoles via 1,2-hydrogen atom transfer (1,2-HAT) to rapidly synthesize indolo[2,1- a ]isoquinoline derivatives under mild conditions. This method affords a variety of indolo[2,1- a ]isoquinoline compounds in good to excellent yields. In contrast to previous reports that relied on transition-metal catalysis or harsh reaction conditions, this strategy offers multiple advantages, including mild and metal-free reaction conditions, a radical tandem reaction mechanism involving a 1,2-HAT process, a wide range of compatible substrates, and excellent tolerance toward functional groups.
Source: ACS Omega
Institutions: Hubei University of Medicine, Taihe Hospital
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W7161989703