The expression of the growth associated protein GAP-43 in injured and regenerating retinal ganglion cells of the adult rat /
Year: 1988
Type: dissertation
Abstract: The lack of axonal regeneration in the adult mammalian CNS has been correlated with the apparent inability of these neurons to increase their expression of the growth associated protein, GAP-43 in response to injury. Here are reported studies of the expression of GAP-43, in retinal ganglion cells (RGCs) of the adult rat whose axons were cut at different distances along the optic nerve or cut immediately behind the eye and allowed to regenerate along peripheral nerve grafts. The immunocytochemical and axonal transport studies demonstrate that injured and regenerating RGCs synthesize and transport increased levels of GAP-43. The enhanced GAP-43 immunoreactivity and transport is triggered by axonal injury and the heightened transport of GAP-43 follows a time course which is influenced by axonal growth. The increased expression of GAP-43 and axonal regeneration into peripheral nerve grafts occur predominantly when axons are cut near their cell bodies suggesting that enhanced GAP-43 expression may be involved in the regulation of neuronal response required for axonal regrowth.
Source: eScholarship@McGill (McGill)
DOI: 10.82308/36966
Author: Lozano, Andres M.
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7065814278