Over four minutes of pyruvate T1 using chemically and physically induced deceleration of relaxation
Year: 2026
Type: article
Abstract: [1- 13 C]pyruvate is the most widely used probe for hyperpolarized metabolic magnetic resonance imaging, with profound applications in tumor and inflammation diagnosis as well as treatment monitoring. The most fundamental hurdle to broader application, however, remains the rapid relaxation of polarization and the associated signal loss. Here, we report a method to address this challenge. Studying the nuclear spin relaxation dispersion of [1- 13 C]pyruvate across magnetic fields from 8 μT to 9.4 T, as a function of additives, solvents, and preparation methods, allows us to achieve T 1 relaxation times of up to four minutes. Such a long T 1 could enable reliable quality control and nearly polarization loss-free transport, further boosting the power of hyperpolarized metabolic MRI. The power of the optimized protocol for T 1 elongation in vitro is showcased by more than doubling the sensitivity in a metabolic experiment.
Source: Nature Communications
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: G1003206793, G1148067206, G1502266186, G1614854811, G2149810171, G2184089736, G2819565804, Advancing Sensitivity, Selectivity, and Relaxation Theory in Zero- and Ultralow-Field Spectroscopy, Parawasserstoffinduzierte Hyperpolarisation von 13Cmarkierten Ketocarbonsäuren für medizinische Anwendungen: Synthese, Polarisationsübertragung, 13CMRT, WIR! - BlueHealthTech - Verbundvorhaben: Translation innovativer Bildgebung und Visualisierungen für die Wirksamkeit mariner Extrakte (hyperquant), TP1: Hyperpolarisierungsphysik, präklinische und klinische Anwendung, G5752782851, G6316168132, G6693189664, G902585018
OpenAlex ID: W7161994083