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A quantitative screening strategy based on activity-content ratio for prioritizing bioactive compounds in medicinal plants

Year: 2026
Type: article
Abstract: of 15.21 ± 1.23 μM. The consistent performance of the ACR model across two distinct enzymatic targets and chemical families (alkaloids and flavonoids) demonstrates its reliability and broad applicability. This study provides a reliable and efficient quantitative tool for bioactivity evaluation, which is expected to greatly accelerate the discovery and quality control of bioactive medicinal plants.
DOI: 10.1016/j.jpha.2026.101665
Authors: Lin Chen, Xinxin Chen, Shengnan Pi, Ditong Huang, Manhuayun Zhai, Jincai Wang, Zhengjin Jiang, Tingting Zhang
Institution: Jinan University
Language: English
Subfield: Drug Discovery
Open Access status: gold
Estimated APC paid: $1,950
OpenAlex ID: W7162004807
FWCI:
Cites: 34
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Related to: 10