Work

Myocardial expression of ADGRL4 and AQP7 is related to regression of left ventricular hypertrophy after aortic valve replacement in a sex-dependent manner

Year: 2026

Type: article

Abstract: Regression of left ventricular hypertrophy is associated with better long-term outcome. This study demonstrates a significant relationship between ADGRL4 and AQP7 gene expression in perioperatively collected myocardial tissues and the regression of left ventricular mass postoperatively in male patients with aortic stenosis only. This could contribute to the development of a sex-based tool to predict the extent of postoperative hypertrophy regression.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00188.2026

Authors: Kristján Bjarki Halldórsson, Korina Karagianni, Adelino F. Leite-Moreira, Dimitra Dafou, Inês Falcão-Pires, Georgios Kararigas

Institutions: University of Iceland, Aristotle University of Thessaloniki, Universidade do Porto, University of Nicosia

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Hellenic Foundation for Research and Innovation