Work

A surgical epicardial approach to mapping and ablation in large animal models

Year: 2026

Type: article

Abstract: Large animal surgeries are the standard for validating pre-clinical electrophysiology studies, and serve as an important step for the rationale underlying clinical trials. Although electrophysiologists receive extensive training in catheter-based approaches, few medical centers have the capability to perform experimental animal surgeries in large animals. Here, we present a step-by-step guide to performing an epicardial approach to pacing and sensing in a large animal sheep model, with the goal of enabling a wide variety of pacing and ablation options.

Source: Journal of Interventional Cardiac Electrophysiology

DOI: 10.1007/s10840-026-02353-3

Authors: Ken S. Lizama, Abdelmotogaly Elgalad, Tirth A. Patel, Matthews John, Mehdi Razavi, Mark D. McCauley

Institutions: University of Illinois Chicago, Jesse Brown VA Medical Center, Baylor College of Medicine

Language: English

Topic: Cardiac Arrhythmias and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890