Work

Anticancer activity of fluoxetine Janus dendrimer against cancer cells

Year: 2026

Type: article

Abstract: anticancer effects of sulindac, ketoprofen, celecoxib and the antidepressant fluoxetine, both free and coupled with synthesized dendrons and dendrimers, on the proliferation and apoptosis of human MCF-7 (human mammary adenocarcinoma), SKLU-1 (human lung adenocarcinoma) and as a control the normal monkey kidney (COS-7) cell line. The antiproliferative activity and cytotoxicity of tested NSAIDs on MCF-7 and SKLU-1 cell lines were assessed by the sulforhodamine B (SRB) assay. The tested dendrons with NSAIDs showed activity against the tumour cell lines. Significant inhibition of the growth of cancer cells was observed for the Janus dendrimers with sulindac-celecoxib, which was selective against MCF-7; and Janus dendrimers with fluoxetine were highly cytotoxic. The fluoxetine-dendrimer could be a candidate for the development of new pharmacological strategies for the treatment and prevention of MCF-7 cancer.

Source: Artificial Cells Nanomedicine and Biotechnology

DOI: 10.1080/21691401.2026.2672826

Authors: Marcos Martínez-García, Isabel Hernández-Rioja, Israel Barajas-Mendoza, Alberto Espinosa-Hernández, Teresa Ramirez-Apan, Elena Martínez-Klimova

Institutions: Universidad Nacional Autónoma de México, Åbo Akademi University

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,557