Work

Mechanistic insights into the anti-metastatic effects of calycosin from Ruanjianhugan tablets on hepatocellular carcinoma via CHEK1 targeting: a network analysis

Year: 2026

Type: article

Abstract: , CCK-8, colony-formation, Transwell and Western-blot assays showed that Cal markedly suppressed HCC-cell proliferation, colony formation, migration, invasion and epithelial-to-mesenchymal transition. In xenograft nude-mouse and tail-vein lung metastasis models, exogenous Cal bound CHEK1 and thereby inhibited HCC metastasis and tumor growth. Collectively, these results not only establish Cal as the core pharmacodynamic component of Ruanjianhugan tablets but also unveil a novel Cal-CHEK1 axis underlying anti-HCC metastasis.

Source: Korean Journal of Physiology and Pharmacology

DOI: 10.4196/kjpp.25.327

Authors: Peiqi Wan, Zhihong Liu, Kai Li, Zhang Wen, Qiuyue Ning, Fang Xiao

Institutions: Guangxi Medical University, First Affiliated Hospital of GuangXi Medical University

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Guangxi Zhuang Region Health Department