Clinical Impact of Baseline ctDNA RAS/BRAF Mutations on Conversion Surgery and Outcomes in First-Line Anti-EGFR Therapy for Advanced Colorectal Cancer
Year: 2026
Type: article
Abstract: Epidermal growth factor receptor (EGFR) blockade combined with cytotoxic chemotherapy has substantially improved outcomes in unresectable metastatic colorectal cancer (mCRC), particularly in patients with left-sided RAS wild-type disease [...]
Source: Cancers
Authors: Takeshi Yamada, Takeshi Nagasaka, Nobuhisa Matsuhashi, Takao Takahashi, Keiji Hirata, Yuki Nakamura, Kiichi Sugimoto, Keiji Koda, Kazuhiro Hiramatsu, Hiroshi Matsuoka, Hidekazu Kuramochi, Akihisa Matsuda, Hideyuki Ishida, Kozo Kataoka, Hajime Yokomizo, Yoshinori Kagawa, Mitsukuni Suenaga, Hiroshi Yoshida
Institutions: Nippon Medical School, Kawasaki Medical School, Gifu University, University of Occupational and Environmental Health Japan, Wakayama Medical University, Juntendo University, Teikyo University, Toyohashi Municipal Hospital, Fujita Health University, NTT (Japan), Saitama Medical University, Hyogo Medical University, Tokyo Women's Medical University Adachi Medical Center, Osaka International Cancer Institute, Institute of Science Tokyo
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W7162076045