Cover Feature: Boronic Acid‐Assisted Cellular Delivery of Pallado‐Fingers for Enhanced Pd(II)‐Mediated De‐Propargylation in Mammalian Cells (Chem. Methods 6/2026)
Year: 2026
Type: article
Abstract: The Cover Feature shows pallado-fingers, PdII complexes derived from Cys2His2 zinc finger domains, engineered into a His2 scaffold (ZFP2H) for catalytic intracellular de-propargylation. Incorporation of 4-carboxyphenylboronic acid into lysine residues generated ZFP2HBA. A PdCl2 complex with ZFP2HBA resulted an enhanced cellular uptake and achieved a tenfold increase in intracellular depropargylation activity. More information can be found in the Research Article by P. Ghosh (DOI: 10.1002/cmtd.70102). Created in BioRender. M, W. (2026) https://BioRender.com/9exe770.
Source: Chemistry - Methods
DOI: 10.1002/cmtd.70127
Author: Pritam Ghosh
Institution: Humboldt-Universität zu Berlin
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,750
OpenAlex ID: W7162104454
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