Integrating haplotype-enhanced HIV surveillance with national databases improves the resolution of transmission networks, drug resistance, and risk assessment
Year: 2026
Type: article
Abstract: < 0.001). Among detected drug-resistant mutations, 69.7% were observed only at the haplotype level, and resistance patterns varied within the same genetic similarity-based cluster. These findings demonstrate that haplotype integration markedly enhances HIV molecular surveillance by resolving previously unrecognized links, clarifying diversity-associated network structure (which may partly reflect infection stage), and detecting low-frequency drug resistance missed by consensus methods.
Source: Emerging Microbes & Infections
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,643
Awards: G3537720931, G45848722
OpenAlex ID: W7162124424