It takes two: A two-component system to visualize single-molecule HIV-1 infection in vivo
Year: 2026
Type: article
Abstract: Understanding HIV-1 reservoir and dynamics is critical to identifying interventions leading to eventual eradication of latently infected cells required for HIV cure.1,2 In the previous issue of Molecular Therapy Advances, the Di Nunzio lab presents an elegant in vivo model system to visualize replication competent HIV-1-infected cells after transplanting modified human hematopoietic stem and progenitor cells (HSPCs).3 This two-component ANCH-OR-GFP system, derived from a chromosomal segregation system in bacteria,4 allows single-molecule visualization of virus infection dynamics.
Source: Molecular Therapy Advances
Author: Amanda M. Dudek
Institution: University of Iowa
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Funder: National Institutes of Health
OpenAlex ID: W7162128152