Work

FTO demethylates Cyclin E1/D1 mRNA and inhibits non-small cell lung cancer cell EMT and proliferation

Year: 2026

Type: article

Abstract: A modification in NSCLC cells. FTO attenuates IGF2BP2-mediated mRNA stability of Cyclin E1 and Cyclin D1, supporting the notion that FTO suppresses EMT and proliferation in NSCLC cells via an IGF2BP2-dependent mechanism. Taken together, our findings highlight the critical role of FTO in regulating Cyclin E1 and Cyclin D1, and establish the interaction mechanism between FTO and Cyclin E1/Cyclin D1 in controlling EMT and proliferation in NSCLC cells.

Source: Cellular Signalling

DOI: 10.1016/j.cellsig.2026.112615

Authors: Zelong Sun, Leyang Shi, Ye Wang, Zheng Zhou, Jianbo Liu

Institutions: Zhengzhou University, Second Affiliated Hospital of Zhengzhou University, Third Affiliated Hospital of Zhengzhou University

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550