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Multiparametric Ultrasound Diagnosis of Focal Prostate Diseases Using Compression Elastography

Year: 2026

Type: article

Abstract: Background: Timely detection of prostate cancer (PCa) at early stages remains a critical challenge in modern urology. Compression elastography is an innovative ultrasound-based technique that provides qualitative assessment of tissue stiffness via color-coded cartographic mapping. Objective: To evaluate the diagnostic value of multiparametric transrectal ultrasound (TRUS) combined with compression elastography for early and differential diagnosis of prostate focal lesions. Methods: A total of 146 male patients (age range: 48–85 years) were examined using TRUS with simultaneous gray-scale imaging, color/power Doppler mapping, and real-time compression elastography, divided into three groups: BPH (n=47), suspected PCa (n=70), and histologically verified PCa (n=29). MRI was the reference standard in 89 cases. Results: Types 3–4 elastograms (high stiffness) were found in 99.9% of verified PCa cases versus 12.8% of BPH patients (p<0.05). Overall diagnostic sensitivity was 93.1%, specificity 87.2%, and accuracy 90.6%. Conclusions: Multiparametric TRUS with compression elastography is a highly informative non-invasive method for early PCa detection and facilitates appropriate patient selection for targeted biopsy.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20356279

Authors: Mamadalieva, Ya.S., Pulatova, I.Z., Khushnazarov, Kh.Kh., Shamsieva, L.E., Shomansurova, N.H.

Language: English

Topic: Ultrasound Imaging and Elastography

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7162202625

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