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The Impact of Coronary Artery Disease in Patients With Peripheral Artery Disease Undergoing Lower-Extremity Revascularization for Chronic Limb-Threatening Ischemia

Year: 2026

Type: article

Abstract: The most severe form of peripheral artery disease (PAD), chronic limb-threatening ischemia (CLTI), is marked by rest pain, nonhealing ulcers, or gangrene. PAD, a manifestation of atherosclerosis, significantly increases the risk of major adverse cardiovascular events (MACEs) and death. More than half of patients with less severe PAD also have coexistent coronary artery disease (CAD). The BEST-CLI trial (Best Endovascular vs Best Surgical Therapy in Patients With Critical Limb Ischemia; URL: https://www.clinicaltrials.gov; Unique identifier: NCT02060630) tested the optimal method of infrainguinal revascularization. The primary outcome was a composite of major adverse limb events (MALEs) or death from any cause. MACEs, MALEs, and total death were secondary outcomes. We examined the effect of CAD on these outcomes in BEST-CLI participants.

Source: UNC Libraries

DOI: 10.17615/0w6m-jg43

Authors: Jaff, Michael R., Rosenfield, Kenneth, Hamdan, Allen, Menard, Matthew T., Drooz, Alain T., Beckman, Joshua A., Creager, Mark A., Hussein, Mohamad, Strong, Michael B., Kashyap, Vikram S., Doros, Gheorghe, McGinigle, Katharine L., Huber, Thomas, Semel, Marcus E., Farber, Alik

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Peripheral Artery Disease Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7162203324

FWCI:

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