Work

Black raspberry improves synaptic function and reverse aβ-induced insulin signaling impairment

Year: 2026

Type: article

Abstract: Synapse dysfunction and impaired insulin signaling are important pathological features of Alzheimer's disease, leading to reduced glucose metabolism and neuronal energy deficits. This study evaluated the effect of black raspberry supplementation on synaptic function and insulin signaling using HT-22 cells. Synaptic markers, insulin signaling proteins, autophagy related proteins markers and downstream signaling molecules associated with tau phosphorylation were analyzed using molecular approaches. Obtained results showed that black raspberry and its ethanolic fraction significantly improved synaptic markers, restored insulin signaling, reduced tau hyperphosphorylation and normalized autophagy through suppression of mTOR signaling. These findings suggest that black raspberry may exert neuroprotective effects by improving synapse function and attenuating insulin resistance associated pathology in Alzheimer's disease models. Further validation in animal and clinical studies is required.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2026.107356

Authors: Yohanes Tandoro, Thangaleela Subramanian, Hui-Fang Chiu, You-Cheng Shen, Chih-Li Lin, Chin-Kun Wang

Institutions: Universitas Katolik Widya Mandala Surabaya, Chung Shan Medical University, Ministry of Health and Welfare, Taichung Hospital

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800