Work

Enhancing collagen functionality through chemical, physical, and enzymatic modification strategies: review

Year: 2026

Type: article

Abstract: Collagen, a vital component of connective tissues, has garnered significant attention in the fields of tissue engineering and biomedical applications due to its biocompatibility and structural properties. However, native collagen’s inherent limitations, such as rapid degradation and limited mechanical strength, necessitate modification to optimize its functionality. This review examines the latest techniques for collagen modification, including physical, chemical, and biological approaches. Chemical crosslinking method, such as the use of glutaraldehyde and carbodiimides, are explored for their ability to enhance collagen’s mechanical stability and resistance to enzymatic degradation. Enzymatic modifications, including treatments with transglutaminase and lysil oxidase, are evaluated for their role in mimicking natural crosslinking process. These advanced modifications techniques have shown promise in creating tailored collagen-based materials.

Source: Polymer Bulletin

DOI: 10.1007/s00289-026-06457-8

Authors: Norfazilah Muhamad, Dayang Norulfairuz Abang Zaidel

Institution: University of Technology Malaysia

Language: English

Topic: Collagen: Extraction and Characterization

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,790

Funder: Universiti Teknologi Malaysia