Determination of long-term therapeutic reactive oxygen and nitrogen species generated by a cold atmospheric plasma brush for burn wound treatment
Year: 2026
Type: article
Abstract: Cold atmospheric plasma technologies are emerging as new tools for the treatment of burn wounds. We utilize ultraviolet–visible spectroscopy (UV–Vis) to determine the long-term reactive oxygen and nitrogen species (RONS) that are responsible for wound healing, generated by our unique cold plasma brush device with working gas of either argon only (Ar) or a mixture of argon with nitrogen (Ar + N 2 ). Our findings demonstrate that the concentration of RONS in the plasma activated deionized water depends on treatment time. We plasma treat agarose gels as a substitute for a skin diffusion model. Ar + N 2 plasmas generate RONS that diffuse through the agarose, suggesting that RONS easily diffuse subcutaneously. The therapeutic potential of the cold plasma is assessed using a rat burn wound model, which indicates that plasma treatments induce substantial healing 8 d post-burn. This study suggests that the cold plasma brush may be suitable for treating burn wounds.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,210
OpenAlex ID: W7162325915