Work

Prognostic, not mediating: a six-cohort causal mediation analysis of immune signatures and tumour mutational burden under checkpoint blockade

Year: 2026

Type: article

Abstract: This deposit contains the complete analytical pipeline, harmonised input data, and per-step result tables supporting the re-evaluation of combined-biomarker assumptions in the tumour mutational burden (TMB)-survival association under PD-(L)1 blockade. The analysis re-uses six published, de-identified checkpoint-blockade cohorts in urothelial carcinoma, renal cell carcinoma, melanoma, and non-small cell lung cancer (NSCLC), with 622 samples entering at least one analytical layer, together with one single-cell deconvolution reference (Chen 2020) and one single-cell audit dataset (Sade-Feldman 2018).

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.20081316

Authors: Khalil, Somar, Hamdan, Marwa

Institutions: GlaxoSmithKline (Belgium), University of Debrecen

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7162428130

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