Work

Primary angiosarcoma of the nasal septum: a rare case report and literature review

Year: 2026

Type: article

Abstract: OBJECTIVES: Angiosarcoma is a rare malignant vascular tumour. Its occurrence in the nasal cavity is uncommon, and septal cases are particularly rare. Because symptoms are often non-specific, nasal septal angiosarcoma may initially mimic benign vascular lesion and delay diagnosis. METHODS: We report a 46-year-old woman with recurrent epistaxis and nasal obstruction. Nasal endoscopy and excisional biopsy were performed, with histopathology and immunohistochemistry. RESULTS: Endoscopy revealed a 1.0 × 0.5 cm mass on the anterior septum. The lesion appeared completely excised on gross inspection; however, histopathology demonstrated infiltrative margins with residual tumour at the resection edges. Microscopy showed irregular vascular channels, pleomorphic endothelial cells, high mitotic activity and focal necrosis. Immunohistochemistry confirmed endothelial differentiation. No cartilage invasion was identified on histology. CONCLUSION: This case highlights the diagnostic challenge of nasal septal angiosarcoma and the emphasises the importance of early biopsy, histopathological confirmation and multidisciplinary management.

Source: The Journal of Laryngology & Otology

DOI: 10.1017/s0022215126104678

Authors: Yun Jin Kang, Min Su Kim, Youn Sun Park, Jin-Hee Cho

Institution: Catholic University of Korea

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550