Work

Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model

Year: 2026

Type: article

Abstract: across lobes = 0.471 ± 0.036). The model performed similarly in identification of lobes with accelerated emphysema progression based on predicted ΔALD values in both the COPDGene internal test set (mean lobar area under the receiver operating characteristic curve [AUC], 0.70 ± 0.013) and the ECLIPSE external test set (mean AUC, 0.70 ± 0.009) across ΔALD risk values. Conclusion A CT-based prognostic model of lobe density decline and emphysema progression was developed and evaluated in participants with COPD at chest CT, and model predictions showed positive correlations with observed values. ClinicalTrials.gov registration nos. NCT00608764 and NCT0029255210

Source: Radiology

DOI: 10.1148/radiol.252958

Authors: Ariel Hernán Curiale, Marc Niethammer, Raúl San José Estépar

Institutions: Brigham and Women's Hospital, Harvard University, University of California San Diego

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Alpha-1 Foundation, National Institutes of Health