Seafood consumption and incident diabetes mellitus in middle-aged and elderly Chinese: results from the 4 C study
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: There is an urgent need to implement population-based actions to prevent diabetes mellitus (DM) in China. However, the current knowledge is limited on a prospective association of seafood intake with DM risk in Chinese adults. We aimed to determine the association between seafood consumption and the incident DM in a nationwide cohort of Chinese populations. METHODS: A prospective cohort study of 104,816 participants, free of DM, aged ≥ 40 years across various geographical regions in China was conducted at baseline (China Cardiometabolic Disease and Cancer study). Habitual consumptions of seafood were assessed using a semi-quantitative food frequency questionnaire, and DM was diagnosed according to the WHO 1999 criteria. Primary outcomes were the incident DM, presented as hazard rations (HRs) with 95% confidence intervals (CIs) that were examined with Cox proportional model with adjustments for relevant covariates across quartiles of seafood consumptions, with the lowest quartile as the reference. Dose-response analyses were evaluated using the restricted cubic spline regression with tests for nonlinearity. RESULTS: During the mean follow-up period of 3.60 years, 7,105 incident DM cases were present among the 104,816 participants. Participants at the highest quartile of seafood-consumption amount had a lower risk of DM than those at the lowest (HR: 0.87, 95% CI: 0.80-0.94). There is a steep decrease in the risk of DM with the increasing consumption of seafood within the cumulative amount of 200.00 g/week, which further strengthened gradually thereafter (P for nonlinearity < 0.001). CONCLUSIONS: In the middle-aged, elderly Chinese population, higher seafood consumption was nonlinearly associated with a lower risk of incident DM, and the cutoff amount of 200.00 g/week was appropriate.
Source: Nutrition Journal
Authors: Xiang Hu, Liang Wang, Zhi-yun Zhao, Li-juan Yang, Hui-hui Deng, Wei Pan, Meng-ying Chen, Jie-li Lu, Mian Li, Yu Xu, Min Xu, Tian-ge Wang, Gang Chen, Qin Wan, Gui-jun Qin, Li Yan, Gui-xia Wang, Ying-fen Qin, Zuo-jie Luo, Xu-lei Tang, Ya-nan Huo, Ru-ying Hu, Zhen Ye, Li-xin Shi, Zheng-nan Gao, Qing Su, Yi-ming Mu, Jia-jun Zhao, Lu-lu Chen, Tian-shu Zeng, Xue-feng Yu, Qiang Li, Li Chen, Yin-fei Zhang, You-min Wang, Hua-cong Deng, Chao Liu, Sheng-li Wu, Tao Yang, Yu-fang Bi, Wei-qing Wang, Guang Ning, Fei-xia Shen, Bo Yang, Xue-jiang Gu
Institutions: Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Baylor University, Shanghai Jiao Tong University, Ruijin Hospital, The Affiliated Yongchuan Hospital of Chongqing Medical University, Fujian Medical University, Fujian Provincial Hospital, Southwest Medical University, Affiliated Hospital of Southwest Medical University, First Affiliated Hospital of Zhengzhou University, Sun Yat-sen University, Sun Yat-sen Memorial Hospital, First Hospital of Jilin University, Guangxi Medical University, First Affiliated Hospital of GuangXi Medical University, First Hospital of Lanzhou University, Nanchang University, Jiangxi Provincial People's Hospital, Zhejiang Center for Disease Control and Prevention, Guiyang Medical University, Dalian Municipal Central Hospital, XinHua Hospital, Chinese People's Liberation Army, Shandong University, Shandong Provincial Hospital, Wuhan Union Hospital, Qilu Hospital of Shandong University, Huazhong University of Science and Technology, Tongji Hospital, Second Affiliated Hospital of Harbin Medical University, Jiading District Central Hospital, First Affiliated Hospital of Anhui Medical University, Jiangsu Province Hospital, Karamay Central Hospital
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
OpenAlex ID: W7162490299