Progenitor resilience and the early onset of chronic lung diseases: NHLBI workshop report
Year: 2026
Type: article
Abstract: Lung function peaks in young adulthood and declines with age. Studies suggest that this trajectory may be modifiable, potentially enhancing lung health and resilience to prevent or delay the onset of chronic lung disease. Although significant progress has been made in identifying the lung stem/progenitor cell populations involved in lung repair and homeostasis, their regulation and potential for manipulation to promote respiratory health and resilience remain elusive. To explore these issues, the NHLBI organized a virtual workshop on November 7-8, 2024 that aimed to cover the current scientific landscape, address critical research gaps, and identify challenges, opportunities, and key research questions related to chronic lung disease, with a focus on lung stem/progenitor resilience and its applications in the early diagnosis, prevention, and treatment of chronic lung diseases. This report summarizes the scientific presentations, discussions, and recommendations from the workshop.
Authors: SeungHye Han, Anny Xiaobo Zhou, Amanda M Jamieson, Andrew A Wilson, Bin Zhou, Daniel J Weiss, Dianhua Jiang, Frank McKeon, Harold Chapman, Helen Miranda, Herbert B Schiller, Jayaraj Rajagopal, Jeong H Yun, Jianwen Que, John F Engelhardt, Maria C Basil, Micha Sam Brickman Raredon, Mingxia Gu, Moumita Ghosh, Preetish Kadur Lakshminarasimha Murthy, Purushothama Rao Tata, Ruobing Wang, Shawn Davidson, Susan M Majka, Yohannes Tesfaigzi, Christian R Gomez, Qing Lu, Jose Ordovas-Montanes, Ravi Kalhan
Institutions: Northwestern University, University of Virginia, Brown University, Boston University, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Vermont, Cedars-Sinai Medical Center, University of Houston, University of California, San Francisco, Case Western Reserve University, German Center for Lung Research, Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital, Columbia University, University of Alabama at Birmingham, UAB Medicine, University of Pennsylvania, Yale University, University of California, Los Angeles, University of Colorado Anschutz, University of Illinois Chicago, Duke University, Boston Children's Hospital, National Jewish Health, University of Colorado Denver, National Institutes of Health, National Heart, Lung, and Blood Institute, Broad Institute, Ragon Institute of MGH, MIT and Harvard, Harvard Stem Cell Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Regulation of distal basal cells in terminal and respiratory airway regeneration, Mitochondrial metabolism controls alveolar epithelial cell fate, Loss of progenitor function accelerates lung aging, Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema
OpenAlex ID: W7162506868