Work

Mitochondrial Regulation of the NLRP3 Inflammasome in Diabetic Kidney Disease: From Mechanisms to Therapeutic Strategies

Year: 2026

Type: article

Abstract: Despite current therapies, persistent chronic inflammation remains an important contributor to residual renal risk in diabetic kidney disease (DKD). The NLRP3 inflammasome is a key driver of this inflammatory cascade, with mitochondria serving as a central hub that translates metabolic stress into NLRP3 activation via mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (ox-mtDNA). This review delineates the signaling network of the mitochondria-NLRP3 inflammasome axis in DKD and evaluates its potential as a therapeutic target to improve patient outcomes.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27114819

Authors: Xiangyu Chen, Zhenyu Wu, Kaiyan Yu, Juan Zhang, Hongjie Di

Institution: Nanjing University of Chinese Medicine

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499