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Channeling teamwork: ATP and lipids cooperate to gate P2X receptors

Year: 2026

Type: article

Abstract: P2X receptor structures resolved in a lipid environment reveal how subtype-specific ligand recognition, drug sensitivity, and channel gating are coupled.

Source: Science Advances

DOI: 10.1126/sciadv.aei2053

Authors: Frank Bosmans, Toshimitsu Kawate

Institutions: Vrije Universiteit Brussel, Ghent University, Cornell University

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

OpenAlex ID: W7162516281

FWCI:

Cites: 10

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