Primary Cilium Forces Neuroendocrine Shift in Prostate Cancer through YAP1 Repression and Reduced Mitochondrial Activity
Year: 2026
Type: article
Abstract: , YAP1 inhibition alone did not induce ciliogenesis, whereas cytoskeletal remodeling with jasplakinolide restored cilium assembly and enabled partial NE transdifferentiation. Single-cell RNA-seq analyses further showed enrichment of ciliogenesis-related genes within NE clusters in CRPC. Together, these observations support a model in which primary cilia are closely associated with NE identity and metabolic adaptation, rather than serving solely as passive markers, and suggest a structural-metabolic axis that may represent a source of biomarkers and therapeutic vulnerabilities.
Source: Theranostics
DOI: 10.7150/thno.126688
Authors: Yingbo Guo, Siyong Peng, Thibaud Jamet, Virginie Firlej, Marie Irondelle, Constance Nau, Christophe A. Girard, Kaushal Asrani, Tamara L. Lotan, Romain Huc, Pascale Soyeux, Matthieu Rouleau, Sandra Lacas-Gervais, Amandine Rovini, Samantha Luciano, Olivier Humbert, Renaud Schiappa, Marc Pujalte-Martin, Mathieu Vigneau, Pascal Peraldi, Frédéric Bost, Gwendal Lazennec, Francis Vacherot, Nathalie M. Mazure
Institutions: Inserm, Université Côte d'Azur, La Ligue Contre le Cancer, Centre Méditerranéen de Médecine Moléculaire, Université Paris-Est Créteil, Institut Mondor de Recherche Biomédicale, Johns Hopkins University, Johns Hopkins Medicine, Centre National de la Recherche Scientifique, Laboratoire de PhysioMédecine Moléculaire, Contrôle de l’Activation cellulaire, Progression Tumorale et Résistance thérapeutique, Université de Limoges, Centre Antoine Lacassagne, École Nationale Vétérinaire de Toulouse, RESTORE, Université de Toulouse
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W7162524091