Year: 2026
Type: article
Abstract: Hop is an essential ingredient in brewing, providing beer with its characteristic bitterness and aroma. Most modern hop cultivars are hybrids between European and North American hop lineages, but how these ancestries contribute to bitter acid content, the most important trait in hop breeding, remains unclear. Here, we report chromosome-scale, haplotype-resolved assemblies of the hybrid hop cultivar Apollo, assign European and North American ancestry across the genome, and identify varying levels of recombination suppression between chromosomes of either origin. Using this reference, we uncover genetic and chemical diversity in core bittering pathways between European and North American hops. We further show additive effects of beneficial European and North American alleles on bitter acid content, providing a foundation for genomics-assisted hop breeding.
Source: Nature Communications
Authors: Sandip Mallikarjun Kale, Heidrun Gundlach, Oliver Gericke, Nadia Kamal, Aldo Almeida, Nicholi Pitra, Nicholas Price, Georg Haberer, Thomas Lux, Flavia Krsticevic, Oliver Kemp, Louise de Bang, Axel Himmelbach, Sudharsan Padmarasu, Mark-Timothy Rabanus-Wallace, Lucie Horáková, Václav Bačovský, Kasper Nielsen, Nanna Bjarnholt, Nikola Micic, Isabella Kruse-Andersen, Birger Lindberg Møller, Christian Janfelt, Birgitte Skadhauge, Paul D. Matthews, Klaus F. X. Mayer, Nils Stein, Martin Mascher, Manuel Spannagl, Alexander Feiner, Ilka Braumann
Institutions: Aarhus University, Carlsberg Laboratory, Carlsberg Group (Denmark), Helmholtz Munich, Technical University of Munich, Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Czech Academy of Sciences, Czech Academy of Sciences, Institute of Biophysics, University of Copenhagen, Martin Luther University Halle-Wittenberg, German Centre for Integrative Biodiversity Research, Murdoch University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
SDG: Zero hunger
Open Access status: gold
Estimated APC paid: $6,990
Awards: G2542470038, G3271687042, G6307380398
OpenAlex ID: W7162552275