Work

Gold Nanoparticles in Central Nervous System Diseases: Recent Progress, Challenges, and Therapeutic Opportunities

Year: 2026

Type: article

Abstract: Central nervous system (CNS) diseases, including neurodegenerative disorders and brain cancers, remain leading causes of disability and death, largely due to limited drug penetration across the blood-brain barrier (BBB). Gold nanoparticles (AuNPs) have emerged as versatile platforms for CNS applications, with tunable morphology, surface chemistry, and optical properties, enabling both therapeutic and diagnostic use. This review highlights recent advances in the design and optimization of AuNPs for brain-targeted delivery, explores their applications in CNS diseases, and discusses current challenges, safety considerations, and future prospects for clinical translation.

Source: Nano Letters

DOI: 10.1021/acs.nanolett.6c00540

Authors: Shunping Han, Salima Bouchrara, Khuloud T. Al-Jamal

Institutions: King's College London, University of Hong Kong

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500