Evaluation of the Safety and Efficacy of SOF/VEL Treatment and Pre-treatment of TAF in Patients with Chronic Hepatitis B Virus/Hepatitis C Virus Coinfection: A Multicenter Study
Year: 2026
Type: article
Abstract: Background and Aims: Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection are among the leading causes of chronic liver diseases worldwide. Through the same transmission routes, HBV/HCV coinfection is widespread and aggravates liver damage. In this study, we aimed to assess the safety and efficacy of sofosbuvir/velpatasvir (SOF/VEL) and the pre-treatment of tenofovir alafenamide fumarate (TAF) on HBV reactivation in HBV/HCV coinfected patients. Methods: < 0.05. Results: < 0.05) significantly decreased after treatment in Group 2. Two patients in Group 1 with genotype 3 showed HBV reactivation and HCV relapse, respectively. No drug-related adverse events were observed in the study. Conclusions: SOF/VEL effectively achieves a sustained virologic response and improves liver function, with an acceptable safety profile in chronic HBV/HCV coinfected patients, including those with compensated cirrhosis, who achieved modest improvement in non-invasive fibrosis indices. Pre-administration of TAF may mitigates the risk of HBV reactivation in this population.
Institutions: Peking University First Hospital, Second Affiliated Hospital of Chongqing Medical University, Fujian Medical University, Mengchao Hepatobiliary Hospital, First Affiliated Hospital of GuangXi Medical University, First People's Hospital of Yunnan Province, Second Affiliated Hospital of Nanchang University, Shihezi University, First Affiliated Hospital of Shihezi University Medical College, First Affiliated Hospital of Xinjiang Medical University, Capital Medical University, Beijing Friendship Hospital, Shanxi Medical University, First Hospital of Shanxi Medical University, First Hospital of Lanzhou University, Henan Provincial People's Hospital, Hebei Medical University, Third Hospital of Hebei Medical University, Hainan General Hospital, Renmin Hospital of Wuhan University
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Gilead Sciences, Lanzhou University, Capital Medical University, Shihezi University, Chongqing Medical University, Nanchang University, Xinjiang Medical University, Wuhan University, Shanxi Medical University, Guangxi Medical University, Hebei Medical University, Fujian Medical University, Henan Provincial People's Hospital, National Science and Technology Major Project, Renmin Hospital of Wuhan University, Beijing Friendship Hospital, Capital Medical University
OpenAlex ID: W7162637830
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