Ocular Biometric and Fundus Characteristics in High Myopia: Protocol for a Hospital-Based Cross-Sectional Study
Year: 2026
Type: article
Study design: Study Protocol
Abstract: Background High myopia (spherical equivalent refractive error [SER] ≤–6.00 diopters) is a prominent global cause of visual impairment, but its structural alterations are inadequately documented at all severity levels in Indian tertiary hospitals. Objective The aim of this study is to evaluate ocular biometric and fundus traits in high myopia and their relationship to the severity of myopia. The primary outcome is axial length measured using contact A-scan biometry. Meta-Analysis for Pathologic Myopia (META-PM) identified fundus changes, keratometry, central corneal thickness, and refractive astigmatism as secondary outcomes. Methods This hospital-based cross-sectional observational study at Acharya Vinoba Bhave Rural Hospital, India, will enroll 160 participants aged 10 to 50 years with high myopia (SER ≤−6.00 diopters in ≥1 eye) consecutively over 2 years. Ophthalmic examination will include best-corrected visual acuity (converted to logarithm of the minimum angle of resolution [logMAR]), cycloplegic refraction, slit-lamp biomicroscopy, keratometry, pachymetry, A-scan biometry, and dilated fundus examination (META-PM). Statistical analysis will involve the Shapiro-Wilk test, Pearson/Spearman correlation, ANOVA/Kruskal-Wallis, chi-square, and generalized estimating equations using SPSS (version 23; IBM Corp). Results The study received ethics approval on July 9, 2025. Enrollment has been ongoing since January 2026. Results are expected to be published in 2027 or 2028. Conclusions This study will provide region-specific data and guide evidence-based high myopia management.
Source: JMIR Research Protocols
DOI: 10.2196/96402
Authors: Anshool Kumbhare, Pranaykumar Shinde
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,900
OpenAlex ID: W7162676937