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Serum metabolic biomarkers associated with self-reported chronic rhinosinusitis: a population-based cross-sectional study from the KNHANES

Year: 2026

Type: article

Abstract: OBJECTIVES: Chronic Rhinosinusitis (CRS) is a prevalent condition with complex pathophysiology. While metabolic factors have been suggested to play a role in CRS, the relationship between serum metabolic markers and CRS prevalence remains unclear. METHODS: This cross-sectional study used data from the 2022 Korean National Health and Nutrition Examination Survey to assess the relationship between serum lipid profiles, glucose metabolism, purine metabolism, and CRS prevalence. A total of 4,759 participants with complete data were included. CRS diagnosis was determined based on self-reported information obtained during health interviews. Serum metabolic markers were measured from fasting blood samples. Logistic regression analyses were conducted to calculate Odds Ratios (OR) and 95% Confidence Intervals (95% CI), while controlling for potential confounding factors. RESULTS: After controlling for confounders, high serum Uric Acid (UA) levels were significantly associated with a higher risk of CRS (OR = 1.558, 95% CI 1.040, 2.332, p = 0.020). Subgroup analysis revealed a stronger correlation among urban residents (OR = 1.635, 95% CI 1.085, 2.463, p = 0.019). However, no marked association was identified between serum indices of lipid metabolism and glucose metabolism and the prevalence of CRS. CONCLUSION: This study found that higher serum UA levels were associated with the presence of CRS, suggesting a potential link between metabolic dysregulation and CRS susceptibility. Further longitudinal and experimental studies are needed to confirm these associations and clarify the underlying mechanisms. LEVEL OF EVIDENCE: Level 4 (Cross-sectional study).

Source: Brazilian Journal of Otorhinolaryngology

DOI: 10.1016/j.bjorl.2026.101838

Authors: Han Chen, Lin Wang, Jisheng Zhang, Xudong Yan, Longgang Yu, Yan Jiang

Institutions: Qingdao University, Affiliated Hospital of Qingdao University, Fujian Provincial Hospital, Fuzhou University

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,070