Work

Synthesis of Janus gold-magnetic nanoparticles for photothermal cancer therapy

Year: 2026

Type: article

Abstract: Background . Tumoricidal photothermal therapies by multimodal nanoplatforms with spatiotemporal precision have gained much attention in recent years, however, developing biocompatible, multifunctional nanosystems for real-time tumor targeting and therapy monitoring remains a critical need. Methods . A novel class of epidermal growth factor receptor (EGFR)-specific aptamers modified Janus gold-coated magnetic nanoparticles (GMN) was engineered as a multifunctional nanoplatform for tumor-targeted multimodal imaging and photothermal therapy in this study. Results . The unique Janus nanostructure features of the strategic nanosystem enables dual functionality, firstly for magnetic resonance imaging guidance through the superparamagnetic nanoparticles, secondly for active tumor targeting combined with near-infrared-responsive photothermal ablation mediated by the gold nanostructure. Conclusions . The demonstrated synergistic capabilities of EGFR aptamer modified GMN established a promising platform for developing next-generation theranostic agents to combine precise cancer diagnosis with spatially controlled therapeutic intervention.

Source: Nanotechnology

DOI: 10.1088/1361-6528/ae7426

Authors: Xiaohui Tan, Lifeng Qi

Institution: Tongji University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,325