Work

Mechanically Assisted PO, PN, and PS Bonds Formation

Year: 2026

Type: article

Abstract: We report a general and efficient mechanochemical protocol for the formation of PO, PN, and PS bonds through the reaction of phosphoryl chlorides with O‐, N‐, and S‐centered nucleophiles. The transformation proceeds under solvent‐free conditions using ball milling in the presence of triethylamine and an inert grinding auxiliary, under ambient atmosphere and short reaction times. A broad range of primary and secondary alcohols, phenols, amines, anilines, and thiols are compatible with the methodology, affording the corresponding phosphates, phosphoramidates, and thiophosphates in moderate‐to‐excellent yields.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70568

Authors: Camilo Morales‐Manrique, Mónica Rey‐Montaño, Daniela Torres‐Ruiz, Carlos Bermudez‐Gonzalez, Diego Gamba‐Sánchez

Institution: Universidad de Los Andes

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,650

Funder: Universidad de los Andes