Work

Sulfoximine and Triazine-Acid Adduct Behavior in Aqueous HPMC: A Fast and Convenient N -Functionalization of Sulfoximines

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Sulfoximines are valuable scaffolds in pharmaceuticals, yet their aqueous-phase stability and reactivity remain underexplored. We report a systematic study of sulfoximine–carboxylic acid coupling in water using hydroxypropyl methylcellulose (HPMC) as a microenvironment. In situ 19 F NMR revealed potential key intermediates and the critical role of LiCl in their stabilization in water. The optimized protocol tolerates diverse functional groups, operates under mild conditions, and scales efficiently. These findings enable efficient sulfoximine functionalization and provide mechanistic insights.

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.6c00160

Authors: Dhanush Pradeep Chethikkattil, Ashish Dusunge, Michael Harmata, Wilfried M. Braje, Sachin Handa

Institutions: University of Missouri, AbbVie (Germany)

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry