Pharmacologic disruption of HuR-RNA interactions prevents maladaptive tubular repair and AKI-to-CKD progression
Year: 2026
Type: article
Abstract: This study identifies the RNA-binding protein HuR as a key regulator of maladaptive tubular repair during AKI-to-CKD transition. Pharmacologic disruption of HuR-RNA interactions with the small molecule inhibitor KH3 attenuated tubular injury, inflammation, senescence, and fibrosis in aristolochic acid-induced nephropathy. These findings provide mechanistic insight into posttranscriptional control of kidney injury and establish HuR inhibition as a promising therapeutic strategy to prevent CKD progression following AKI.
Authors: Zhou Wang, Simeng Liu, Lili Zhuang, Yuli Qiu, Jeffrey Aube, Xiaoqing Wu, Liang Xu, Yufeng Huang
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7162762571