Work

Aging mechanisms and rejuvenation strategies for hematopoietic stem cells

Year: 2026

Type: article

Abstract: Hematopoietic stem cells (HSCs) transition through different functional states throughout life from emergence and expansion in the fetus, homeostasis maintenance in adulthood, and progressive functional decline with age. Aged HSCs are characterized by increased phenotypic number, decreased self-renewal and long-term reconstitution capacity, myeloid-biased differentiation, and clonal hematopoiesis. In this review, we summarize the life cycle of HSCs, integrate recent advances in understanding the cell-intrinsic and extrinsic mechanisms that drive HSC aging, and highlight innovative rejuvenation strategies that could be harnessed to delay HSC and systemic aging.

Source: Genome biology

DOI: 10.1186/s13059-026-04119-6

Authors: Yan Zhang, Yanhua Xu, Wanyu Shi, Dandan Cao, De-an Guo, Rui Yue

Institutions: Tongji University, Changchun University of Chinese Medicine, Shanghai East Hospital, Shanghai University of Traditional Chinese Medicine

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,490