Work

Irisin promotes selective changes in hippocampal mitochondrial metabolism in mice

Year: 2026

Type: article

Abstract: Irisin, an exercise-induced hormone, exerts neuroprotective actions in neurological disease models, yet its effects on brain mitochondrial metabolism remain unclear. Here, we examined how irisin influences mitochondrial function and dynamics in the mouse hippocampus. Acute irisin exposure boosted ATP-coupled oxygen consumption without altering mitochondrial content or dynamics-related proteins. Furthermore, chronic irisin administration in vivo decreased hippocampal Opa1 and Drp1 levels, two key regulators of mitochondrial remodeling. These findings uncover selective actions of irisin on hippocampal mitochondrial homeostasis and identify prolonged irisin exposure as a potential regulator of mitochondrial dynamics in the brain.

Source: Biochemistry and Biophysics Reports

DOI: 10.1016/j.bbrep.2026.102657

Authors: Ariene S. Fonseca, Marina S. Chichierchio, Mariana G. Chauvet, Guilherme B. de Freitas, Andréa Tosta, Tiago Ferreira de Lima, Marcos A. Formiga-Jr, Felipe C. Ribeiro, Sergio T. Ferreira, Fernanda G. De Felice, Juliana Camacho-Pereira, Mychael V. Lourenco

Institutions: Universidade Federal do Rio de Janeiro, Queen's University, Instituto de Biofísica Carlos Chagas Filho, D’Or Institute for Research and Education, Universidade Estadual de Campinas (UNICAMP)

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700

Funders: Alzheimer's Association, Instituto Nacional de Ciência e Tecnologia – Frutas Tropicais, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional, Instituto Serrapilheira

Awards: G434043857, G4375429829, G4789148040, G5309594884, G6732054889, G7111769520, G7622770718, G8343890619, G8795164439, G885542991

OpenAlex ID: W7162769290

FWCI:

Cites: 45

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