BurstDR spinal cord stimulation for chronic regional pain syndrome secondary to Castleman’s disease treatment: A case report
Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Castleman's disease is a rare lymphoproliferative disorder that can affect lymph nodes anywhere in the body. Removal of the enlarged lymph nodes may lead to secondary nerve damage, potentially resulting in patients developing complex regional pain syndrome (CRPS) type 2. Spinal cord stimulation (SCS) is a well-established, cost-effective therapy for chronic refractory pain, including CRPS type 2. Case Description: A 32-year-old female who was treated for unicentric hyaline vascular type Castleman's disease. Following neurolysis, she developed CRPS type 2 of the lumbosacral plexus; her symptoms persisted despite pharmacotherapy and physical therapy. She underwent a trial of burst SCS with significant symptom relief, followed by permanent implantation of a Penta paddle lead at the T8 level. Three months postoperatively, she reported marked clinical improvement and was able to discontinue pregabalin. Conclusion: A 32-year-old female with Castleman's disease developed CRPS type 2 secondary to neurolysis that was effectively treated with Burst SCS.
Source: Surgical Neurology International
Authors: Stephen Jaffee, Chinelo Onyiah, Michael D. Patterson, Griffin White, Mokshal H. Porwal, Nestor Tomycz
Institution: Allegheny Health Network
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7162771399