Work

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

Year: 2026

Type: article

Abstract: ABSTRACT In this work, we report a straightforward synthetic procedure that enables the selective functionalization of the C4 position of isoquinoline, followed by subsequent transformations of the resulting products. Although numerous synthetic procedures have been reported for obtaining this relevant class of nitrogen heterocycles, only a few methodologies are available for their functionalization, particularly for modifying the heterocyclic ring. The strategy features an oxidative radical substitution process that generates radicals from readily prepared xanthates. Subsequent transformations of the resulting products demonstrate the synthetic potential to access new compounds.

Source: ChemistrySelect

DOI: 10.1002/slct.73568

Authors: Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez

Institutions: Universidad Nacional Autónoma de México, University of Nariño

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,880

Funder: University of Namibia