Work

Replication and compartmentalization of Dobrava-Belgrade virus in the central nervous system

Year: 2026

Type: article

Study design: Case Report

Abstract: A heart-transplant recipient developed fatal neurologic disease. High-throughput sequencing (HTS) identified Dobrava - Belgrade virus in central nervous system (CNS) and peripheral specimens. Genomic analyzes showed distinct viral populations across compartments, suggesting CNS tropism. This case highlights atypical infection presentations in immunosuppressed patients and underscores the diagnostic value of HTS.

Source: Emerging Microbes & Infections

DOI: 10.1080/22221751.2026.2673649

Authors: Julia Melchert, Julia Herzig-Nichtweiss, Jenny Meinhardt, Farid Salih, Till Dominik Best, Marie Luisa Schmidt, Lisa Jasmin Müller, Talitha Veith, Jörn Beheim-Schwarzbach, Jörg Hofmann, Terry C. Jones, Eberhard Siebert, Felix Schoenrath, Helena Radbruch, Christian Drosten, Victor Max Corman

Institutions: Humboldt-Universität zu Berlin, Stiftung Charité, Freie Universität Berlin, Charité - Universitätsmedizin Berlin, University of Cambridge, Deutsches Herzzentrum der Charité

Language: English

Topic: Viral Infections and Vectors

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,643

Funders: Deutsches Zentrum für Infektionsforschung, National University of Mongolia, Bundesministerium für Bildung und Forschung, Bundesministerium für Bildung und Frauen

OpenAlex ID: W7162788504

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Cites: 15

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